Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell?
T Lazar, M Götte, D Gallwitz - Trends in biochemical sciences, 1997 - cell.com
T Lazar, M Götte, D Gallwitz
Trends in biochemical sciences, 1997•cell.comIn eukaryotic cells, protein transport through the secretory and endocytic pathways is
mediated by vesicular intermediates. Individual transport steps are regulated by Ras-like
guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. The complete
sequencing of the Saccharomyces cerevisiae genome has revealed the total number of Ypt
GTPases in this organism. There is some redundancy among the 11 Ypt proteins, and only
those involved in the biosynthetic pathway are essential for celi viability.
mediated by vesicular intermediates. Individual transport steps are regulated by Ras-like
guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. The complete
sequencing of the Saccharomyces cerevisiae genome has revealed the total number of Ypt
GTPases in this organism. There is some redundancy among the 11 Ypt proteins, and only
those involved in the biosynthetic pathway are essential for celi viability.
Abstract
In eukaryotic cells, protein transport through the secretory and endocytic pathways is mediated by vesicular intermediates. Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. The complete sequencing of the Saccharomyces cerevisiae genome has revealed the total number of Ypt GTPases in this organism. There is some redundancy among the 11 Ypt proteins, and only those involved in the biosynthetic pathway are essential for celi viability.
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