Myelin basic protein-specific T lymphocytes induce chronic relapsing experimental autoimmune encephalomyelitis in lymphocyte-deficient (SCID) mice
RE Jones, M Mass, DN Bourdette - Journal of neuroimmunology, 1999 - Elsevier
Myelin basic protein (BP)-specific T lymphocyte cell lines were selected from the lymph
nodes (LN) of BP-immunized, H-2d, CXJ-1 mice prior to the onset of clinical disease. These
CD4+ T cells induced severe acute experimental autoimmune encephalomyelitis (EAE) in
MHC-compatible (H-2d), lymphocyte-deficient (SCID) mice (CB-17scid/scid). The incidence
of disease was much higher in immunodeficient SCID mice (71%) than in syngeneic
immunocompetent CXJ-1 mice (5%). SCID mice with EAE had an acute progressive …
nodes (LN) of BP-immunized, H-2d, CXJ-1 mice prior to the onset of clinical disease. These
CD4+ T cells induced severe acute experimental autoimmune encephalomyelitis (EAE) in
MHC-compatible (H-2d), lymphocyte-deficient (SCID) mice (CB-17scid/scid). The incidence
of disease was much higher in immunodeficient SCID mice (71%) than in syngeneic
immunocompetent CXJ-1 mice (5%). SCID mice with EAE had an acute progressive …
