Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation …
TT Lu, M Barreuther, S Davis, JA Madri - Journal of Biological Chemistry, 1997 - ASBMB
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is 130-kDa member of the
immunoglobulin gene superfamily that localizes to cell-cell borders of confluent endothelial
cells and has been shown to play a role in the control of endothelial sheet migration and
leukocyte transmigration through the endothelium. The cytoplasmic tail plays an important
role in the modulation of PECAM-1 function. Mutation of tyrosine 663 or 686 in the
cytoplasmic tail reduces phosphorylation and mutation of 686 is associated with a reduction …
immunoglobulin gene superfamily that localizes to cell-cell borders of confluent endothelial
cells and has been shown to play a role in the control of endothelial sheet migration and
leukocyte transmigration through the endothelium. The cytoplasmic tail plays an important
role in the modulation of PECAM-1 function. Mutation of tyrosine 663 or 686 in the
cytoplasmic tail reduces phosphorylation and mutation of 686 is associated with a reduction …
