Structure of tumour necrosis factor
Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an
antiparallel β sandwich. Individual subunits form the trimer by a novel edge-to-face packing
of β sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable
similarity to the'jelly-roll'structural motif characteristic of viral coat proteins.
antiparallel β sandwich. Individual subunits form the trimer by a novel edge-to-face packing
of β sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable
similarity to the'jelly-roll'structural motif characteristic of viral coat proteins.
Abstract
Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel β sandwich. Individual subunits form the trimer by a novel edge-to-face packing of β sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins.
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