Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification
S Jono, C Peinado, CM Giachelli - Journal of Biological Chemistry, 2000 - ASBMB
Osteopontin (OPN) is a non-collagenous, glycosylated phosphoprotein associated with
biomineralization in osseous tissues, as well as ectopic calcification. We previously reported
that osteopontin was co-localized with calcified deposits in atherosclerotic lesions, and that
osteopontin potently inhibits calcium deposition in a human smooth muscle cell (HSMC)
culture model of vascular calcification. In this report, the role of phosphorylation in
osteopontin's mineralization inhibitory function was examined. The ability of OPN to inhibit …
biomineralization in osseous tissues, as well as ectopic calcification. We previously reported
that osteopontin was co-localized with calcified deposits in atherosclerotic lesions, and that
osteopontin potently inhibits calcium deposition in a human smooth muscle cell (HSMC)
culture model of vascular calcification. In this report, the role of phosphorylation in
osteopontin's mineralization inhibitory function was examined. The ability of OPN to inhibit …
