[HTML][HTML] Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB
S Kasibhatla, L Genestier, DR Green - Journal of Biological Chemistry, 1999 - ASBMB
T cell receptor engagement activates transcription factors important for cytokine gene
regulation. Additionally, this signaling pathway also leads to activation-induced apoptosis in
T lymphocytes that is dependent on FasL transcription and expression. Here we
demonstrate that nuclear factor κB (NF-κB), which is involved in the transcriptional regulation
of many cytokine genes expressed in activated lymphocytes, also plays a role in T cell
activation-induced FasL expression. Inhibition of NF-κB activity in a T cell hybridoma leads …
regulation. Additionally, this signaling pathway also leads to activation-induced apoptosis in
T lymphocytes that is dependent on FasL transcription and expression. Here we
demonstrate that nuclear factor κB (NF-κB), which is involved in the transcriptional regulation
of many cytokine genes expressed in activated lymphocytes, also plays a role in T cell
activation-induced FasL expression. Inhibition of NF-κB activity in a T cell hybridoma leads …
