[HTML][HTML] The Tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IκB kinases containing IKKα and IKKβ
ZL Chu, JA DiDonato, J Hawiger, DW Ballard - Journal of Biological …, 1998 - ASBMB
The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV1) chronically activates
transcription factor NF-κB by a mechanism involving degradation of IκBα, an NF-κB-
associated cytoplasmic inhibitor. Tax-induced breakdown of IκBα requires phosphorylation
of the inhibitor at Ser-32 and Ser-36, which is also a prerequisite for the transient activation
of NF-κB in cytokine-treated T lymphocytes. However, it remained unclear how Tax
interfaces with the cellular NF-κB/IκB signaling machinery to generate a chronic rather than …
transcription factor NF-κB by a mechanism involving degradation of IκBα, an NF-κB-
associated cytoplasmic inhibitor. Tax-induced breakdown of IκBα requires phosphorylation
of the inhibitor at Ser-32 and Ser-36, which is also a prerequisite for the transient activation
of NF-κB in cytokine-treated T lymphocytes. However, it remained unclear how Tax
interfaces with the cellular NF-κB/IκB signaling machinery to generate a chronic rather than …
