[HTML][HTML] Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-κB (IκB-αS32/36A) and the implications for vaccine development
I Quinto, M Mallardo, F Baldassarre, G Scala… - Journal of biological …, 1999 - ASBMB
Live-attenuated human immunodeficiency viruses (HIVs) are candidates for Acquired
Immunodeficiency Syndrome (AIDS) vaccine. Based on the simian immunodeficiency virus
(SIV) model for AIDS, loss-of-function (eg deletion of accessory genes such as nef) has been
forwarded as a primary approach for creating enfeebled, but replication-competent, HIV-
1/SIV. Regrettably, recent evidence suggests that loss-of-function alone is not always
sufficient to prevent the emergence of virulent mutants. New strategies that attenuate via …
Immunodeficiency Syndrome (AIDS) vaccine. Based on the simian immunodeficiency virus
(SIV) model for AIDS, loss-of-function (eg deletion of accessory genes such as nef) has been
forwarded as a primary approach for creating enfeebled, but replication-competent, HIV-
1/SIV. Regrettably, recent evidence suggests that loss-of-function alone is not always
sufficient to prevent the emergence of virulent mutants. New strategies that attenuate via …