[HTML][HTML] Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes inDrosophila melanogaster cells
YS Kim, SJ Han, JH Ryu, KH Choi, YS Hong… - Journal of biological …, 2000 - ASBMB
Eukaryotic organisms use a similar Rel/NF-κB signaling cascade for the induction of innate
immune genes. InDrosophila, lipopolysaccharide (LPS) signal-induced activation of the
Rel/NF-κB family transcription factors is an essential step in the transcriptional activation of
inducible antimicrobial peptide genes. However, the mechanism by which the LPS-induced
signaling pathway proceeds remains largely unknown. Here we have cloned a novel
Drosophila LPS-activated kinase (DLAK) that is structurally related to mammalian IκB …
immune genes. InDrosophila, lipopolysaccharide (LPS) signal-induced activation of the
Rel/NF-κB family transcription factors is an essential step in the transcriptional activation of
inducible antimicrobial peptide genes. However, the mechanism by which the LPS-induced
signaling pathway proceeds remains largely unknown. Here we have cloned a novel
Drosophila LPS-activated kinase (DLAK) that is structurally related to mammalian IκB …