Tlr4: central component of the sole mammalian LPS sensor
B Beutler - Current opinion in immunology, 2000 - Elsevier
B Beutler
Current opinion in immunology, 2000•ElsevierMutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional
cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions
as the transmembrane component of the LPS receptor complex, an unduplicated pathway
for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to
LPS signal transduction.
cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions
as the transmembrane component of the LPS receptor complex, an unduplicated pathway
for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to
LPS signal transduction.
Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.
Elsevier