Protein folding in the cell
MJ Gething, J Sambrook - Nature, 1992 - nature.com
MJ Gething, J Sambrook
Nature, 1992•nature.comIn the cell, as in vitro, the final conformation of a protein is determined by its amino-acid
sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the
absence of other macromolecular cellular components, folding and assembly of
polypeptides in vivo involves other proteins, many of which belong to families that have
been highly conserved during evolution.
sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the
absence of other macromolecular cellular components, folding and assembly of
polypeptides in vivo involves other proteins, many of which belong to families that have
been highly conserved during evolution.
Abstract
In the cell, as in vitro, the final conformation of a protein is determined by its amino-acid sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the absence of other macromolecular cellular components, folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.
nature.com
