Apoptosis in proliferating, senescent, and immortalized keratinocytes
V Chaturvedi, JZ Qin, MF Denning, D Choubey… - Journal of Biological …, 1999 - ASBMB
Skin provides an attractive organ system for exploring coordinated regulation of keratinocyte
(KC) proliferation, differentiation, senescence, and apoptosis. Our main objective was to
determine whether various types of cell cycle arrest confer resistance to apoptosis. We
postulated that KC cell cycle and cell death programs are tightly regulated to ensure
epidermal homeostasis. In this report, simultaneous expression of cyclin-dependent kinase
inhibitors (p15, p16, p21, and p27), a marker of early differentiation (keratin 1), mediators of …
(KC) proliferation, differentiation, senescence, and apoptosis. Our main objective was to
determine whether various types of cell cycle arrest confer resistance to apoptosis. We
postulated that KC cell cycle and cell death programs are tightly regulated to ensure
epidermal homeostasis. In this report, simultaneous expression of cyclin-dependent kinase
inhibitors (p15, p16, p21, and p27), a marker of early differentiation (keratin 1), mediators of …
