The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100–150-kDa molecular mass complex
A Capell, J Grunberg, B Pesold, A Diehlmann… - Journal of Biological …, 1998 - ASBMB
Mutations in the presenilin (PS) genes are linked to early onset familial Alzheimer's disease
(FAD). PS-1 proteins are proteolytically processed by an unknown protease to two stable
fragments of∼ 30 kDa (N-terminal fragment (NTF)) and∼ 20 kDa (C-terminal fragment
(CTF))(Thinakaran, G., Borchelt, DR, Lee, MK, Slunt, HH, Spitzer, L., Kim, G., Ratovitsky, T.,
Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, AI, Gandy, SE, Jenkins, NA,
Copeland, NG, Price, DL, and Sisodia, SS (1996) Neuron 17, 181–190). Here we show that …
(FAD). PS-1 proteins are proteolytically processed by an unknown protease to two stable
fragments of∼ 30 kDa (N-terminal fragment (NTF)) and∼ 20 kDa (C-terminal fragment
(CTF))(Thinakaran, G., Borchelt, DR, Lee, MK, Slunt, HH, Spitzer, L., Kim, G., Ratovitsky, T.,
Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, AI, Gandy, SE, Jenkins, NA,
Copeland, NG, Price, DL, and Sisodia, SS (1996) Neuron 17, 181–190). Here we show that …
